Alzheimer’s Disease

Several studies show the usefulness of the neuroprotective effects that cannabinoids can offer in Alzheimer's Disease. The protection of neurons from amyloid material deposition, reduces the progression of cellular degeneration, helping to preserve cognitive and motor abilities, thus improving patient's quality of life.

Medical Cannabis’ effects against Alzheimer’s:

  • Anti-inflammatory.
  • Neuroprotector.
  • Antioxidant.
  • Stops degenerative processes.
  • Analgesic.

Alzheimer’s Disease is a neurodegenerative disease whose origin is still a subject of discussion. One theory that has been widely accepted to define the disease is the deposition of the ß-amyloid protein (Aß) in several regions of the brain. The accumulation of this protein produces small inflammatory spots, which over time leads to neuronal cell death, subsequently changing the neurotransmitter flow and causing the loss of efficient synapses.

Preclinical studies suggest that the endocannabinoid system protects against excess neurotransmitter release, oxidative stress, and inflammation; the key events in the development of Alzheimer’s Disease. It has also been shown that endocannabinoids decrease the permeability of the neuronal membrane, hindering the entry of ß-amyloid protein and preventing the neurons from degenerating. CBD cannabidiol, due to its anti-inflammatory properties, can attenuate the neuroinflammatory responses produced by the cluster of protein.

Recent studies on the therapeutic strategies of this disease have focused on the neuroprotective properties of cannabinoids, which could delay the ongoing neurodegeneration caused by the disease. The anti-inflammatory and antioxidant properties of cannabis derivatives, such as CBD oil, contain beneficial properties to treat Alzheimer’s Disease and other neurodegenerative diseases that may delay the onset of disease-specific symptoms such as dementia.


Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes, 2016. J. Nat. Prod. 2016, 79, 2, 324-331.
Delineating the Efficacy of a Cannabis-Based Medicine at Advanced Stages of Dementia in a Murine Model, 2016. Aso, Estera; Andrés-Benito, Pola; Ferrer, Isidroa.
Dazed and Confused: Medical Cannabis in Alzheimer Disease, 2016. Inga M. Antonsdottir, R.N., B.S.Na, Kelly M. Makino, M.D.b, Anton P. Porsteinsson, M.D.
A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders, 2017. Keane Lim, Yuen Mei See, and Jimmy Lee.
Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model, 2017. Ning-Yuan Chen, Cheng-Wu Liu, Wei Lin, Yi Ding, Zhang-ya Bian, Ling Huang, Hao Huang, Kai-Hui Yu, Si-Bang Chen, Yu Sun, Lei Wei, Jun-Hua Peng, and Shang-Ling Pan.

See more diseases

See more